Lipase Inhibitor Causes And Adverse Effects - 1576 Words

Lipase inhibitor In humans, the first step in dietary fat digestion starts in the stomach with mechanical emulsification and partial TAG hydrolysis by gastric lipase, resulting in the lipolytic products DAG and free fatty acids. (CREY, Carey, Borgstrom) The remaining part of TAG digestion is brought about in the duodenal lumen by pancreatic lipase, which acts mainly on the sn-1 and sn-3 position of TAG molecules, releasing 2-MAG and free fatty acids. (Borgstrom, Mattson) Thus, inhibition of gastric and pancreatic lipases leads to substantial decrease in the absorption of dietary fats. One lipase inhibitor already approved in 1999 by FDA was Orlistat, which was later made available as an over-the-counter drug in 2007 as a weight loss aid for overweight adults under the name Alli to be used along with a reduced-calorie, low-fat diet, and exercise program. It is to be taken in the dose of 60 mg up to three times a day with each fat-containing meal. (fda) It is known to cause undesirable GI-related adverse events such as oily evacuation, flatus with discharge, oily spotting and faecal incontinence, which leads to poor patient compliance. (Finer, Sjostrom, Davidson) Although considered relatively safe, a US consumer advocacy group namely Public Citizen differed strongly in its opinion of Xenical (Orlistat 120 mg dose under prescription) and in Alli (Orlistat 60 mg dose over the counter). Dr Sidney Wolfe, Director of Public Citizen s Health Research Group, declared to the pressShow MoreRelated Diet Pills Essay examples1010 Words   |  5 Pageslose the weight desired i n a short amount of time. Consequently, the drug was found to have unpleasant adverse side effects. These are: mood changes, blurred vision, unpleasant taste or dry mouth, constipation, diarrhea, nausea, vomiting, urinary urgency, false sense of well-being. It was a non-prescription drug easily that could easily be bought by anyone until studies showed much side effects very harmful to ones health. Next and still quite popular with the public are Bankok pills. These pillsRead MoreAn Herbal Supplement Essay1933 Words   |  8 PagesHawthorn to make tea. Several in vivo and in vitro studies have been conducted to determine the effectiveness that Hawthorn has in improving cardiovascular function by vasodilating blood vessels, decreasing arterial blood pressure, and lipid lowering effects (Wang, Xiong, Feng, 2013). 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John Smith, MD. Division of Hematology and Oncology, Department of Internal Medicine. 2) Pharmacology and Indications:4 Pharmacology Ceritinib is a potent inhibitor of anaplastic lymphoma kinase (ALK), a tyrosine kinase involved in the pathogenesis of nonsmall cell lung cancer (NSCLC). ALK gene abnormalities due to mutations or translocations may result in expression of oncogenic fusion proteins, that alterRead MoreObesity : The Problem Of Pediatric Obesity Essay2132 Words   |  9 Pagesconsensus resolves around appropriate responses to the problem. This literature review delves into a single, highly favored approach to managing pediatric obesity: prescription medication. The paper compares and contrasts the efficacy and associated effects of the only two drugs approved by the Food and Drug Administration (FDA) for prolonged management of childhood obesity; sibutramine and orlistat. 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Cancer of the head of the pancreas are small lesions tumors that can cause compression and impair the function of the bile duct. Regardless of the original site on the pancreas it spreads rapidly. Manifestations